Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins

Regulation of G protein-coupled receptor signaling by scaffold proteins.

The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric G proteins, which can activate a wide variety of cellular enzymes and ion channels. G protein-coupled receptors can also interact with a number of cytoplasmic scaffold ...

Regulation of G Protein–Coupled Receptor Signaling By Scaffold Proteins G Protein–Coupled Receptor Oligomerization: Implications for G Protein Activation and Cell Signaling Multi-Tasking RGS Proteins in the Heart: The Next Therapeutic Target?

Regulator of G-protein–signaling (RGS) proteins play a key role in the regulation of G-protein–coupled receptor (GPCR) signaling. The characteristic hallmark of RGS proteins is a conserved 120-aa RGS region that confers on these proteins the ability to serve as GTPase-activating proteins (GAPs) for G proteins. Most RGS proteins can serve as GAPs for multiple isoforms of G and therefore have the...

A direct and functional interaction between the trimeric G protein Go and Rab5 in G proteincoupled receptor signaling

Regulation of hormone signaling by nuclear receptor interacting proteins.

Nuclear receptors are ligand-activated transcription factors which regulate the expression of genes critical for the growth of hormonedependent cancers. Their expression and activity are controlled by various cofactors which are important players in hormone-dependent carcinogenesis. RIP140 is a negative transcriptional regulator which is recruited by agonist-liganded receptors. Its strong repre...

Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action.

In the past years, the relationship between the endocannabinoid system (ECS) and other hormonal and neuromodulatory systems has been intensively studied. G protein-coupled receptors (GPCRs) can stimulate endocannabinoid (eCB) production via activation of G(q/11) proteins and, in some cases, G(s) proteins. In this review, we summarize the pathways through which GPCR activation can trigger eCB re...